Ability of monophosphoryl lipid A to augment the antibody response of young mice

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Ability of monophosphoryl lipid A to augment the antibody response of young mice.

Treatment with nontoxic monophosphoryl lipid A increased the magnitude of the immunoglobulin M (IgM) antibody response to type III pneumococcal polysaccharide in young (2- to 4-week-old) mice. This was accompanied by the appearance of significant numbers of IgG1- and IgG3- secreting antibody-forming cells in 4-week-old mice. These findings indicate that monophosphoryl lipid A can be used as an ...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1988

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.56.12.3064-3066.1988